Unity Walk > The Parkinson's Institute and Clinical Center Research Grants 2016
The Parkinson's Institute and Clinical Center is using its 2016 distribution to fund:
A Two-Year Prospective Longitudinal Study using Quantitative and Qualitative Assessments to Define the Natural History of Gastrointestinal Symptoms in Patients with Parkinson’s Disease or at Risk for Developing the Motor Symptoms of Parkinson’s Disease
|PROJECT TITLE: A Two-Year Prospective Longitudinal Study using Quantitative and Qualitative Assessments to Define the Natural History of Gastrointestinal Symptoms in Patients with Parkinson’s Disease or at Risk for Developing the Motor Symptoms of Parkinson’s Disease
Investigator/Author: C. Barlow PI, G. Triadafilopoulos co-PI, J.W. Langston co-PI, L. Rees co-PI, R. Gandhy co-PI, S. Brillman co-PI, B. Schuele co-PI
Objective: To characterize the natural progression of gastrointestinal symptoms in patients with Parkinson’s disease, or who are at high risk for developing the motor symptoms of Parkinson’s disease, using the Gastrointestinal Symptom Relief Scale (GSRS) and Gastroparesis Cardinal Symptom Index (GCSI); high resolution esophageal manometry to evaluate the functioning of the esophageal muscle and sphincters; high resolution anorectal manometry to evaluate anorectal motility and coordination; and the SmartPill® to measure gastric, colon, and small bowel transit times.
Background: Parkinson’s disease results in progressive accumulation of alpha-synuclein in the neurons of the gastrointestinal tract, resulting in dysfunction and ultimately degeneration of neurons in the gastrointestinal tract which leads to clinically important symptoms that can be quantified and measured over time. Quantitative assessments using newly developed high resolution esophageal and anorectal manometry, and the SmartPill® device may be more sensitive at quantifying gastrointestinal symptoms and may be better endpoints for clinical studies designed for drug approvals than symptom based assessments in Parkinson’s disease.
Methods/Design: This is a single center, prospective, non-interventional, cross-sectional and longitudinal study of the natural history of gastrointestinal symptoms associated with Parkinson’s disease. Data from this study will be used to characterize the progression of gastrointestinal symptoms associated with Parkinson’s disease and determine which outcome measures will be best to assess the efficacy of future potential therapies and to optimize ongoing patient management.
Relevance to Diagnosis/Treatment of Parkinson’s disease: Quantitative assessments may be able to demonstrate improvement or worsening of gastrointestinal dysfunction in relation to changes in medication and therefore be better for diagnosis of gastrointestinal issues and for following response to treatment. Analysis of the gastrointestinal tract may also lead to earlier diagnosis of Parkinson’s disease, quicker referral to specialty centers and improved patient care and patient outcomes.
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